생강추출물을 이용한 손 소독제의 가능성 평가

Evaluation of Possibility for Hand Disinfectant using Ginger Extract

The purpose of this study is to develop potential for hand sanitizer through anti-bacterial test on virulent Eshcherichia coli by ginger extract. In each concentration range (0 &#8211; 0.9%w/v) of ginger extract, the antimicrobial inhibiting effect of E. coli wasn t shown to be statistically distinct mutually (p<0.05). However, in the concentration of 0.7 &#8211; 0.9%w/v in ginger extract, the growth inhibiting activity on E. coli was detected to be 0.21±0.03 and 0.37±0.07 (mm), respectively. Thus, it is judged that the higher concentration in ginger extract leads to have the antimicrobial inhibiting effect. As a result of measuring growth inhibiting activities on E. coli after carrying out heat treatment of ginger extract at 60, 70, 80, 90 and 100℃, respectively, in order to obtain physical and chemical stability of ginger extract, it was indicated (p<0.05) to have statistically distinct influence upon growth inhibiting activities. Also, ginger extract, which was treated by pH degree (pH 2. 4. 6. 8. 10 and 12), did not indicated (p<0.05) statistical influence upon growth inhibiting activities. Hand Sanitizer in the experimental group 1 with the addition of D.W, hydrogenated castro oil, alcohol and ginger extract was measured to be the highest in the antimicrobial inhibiting effect. Also, the result of analyzing (+)ESI (Electroospray Ionization)-HPLC/MS (High Performance Liquid Chromatography/Mass Spectrometry) of gingerol compound in the ginger extract was shown by gingerol compound of ginger on scan 8-gingerol=305[M+H-H2O]m/z were confirmed.