종양유발 인체 감마허피스바이러스를 제어하는 천연 식물화합물의 항바이러스 작용

Antiviral activity of natural phytochemicals against oncogenic human gammaherpesviruses

Abstract Gammaherpesviruses are a subtype of the Herpesviridae family. They undergo lytic replication in epithelial cells and establish latency in lymphocytes, leading to persistent infection in the host. Human gammaherpesviruses are called oncogenic viruses, as their infections are associated with various types of cancers. Therefore, the control of human gammaherpesviruses is important for the treatment of virus-associated cancers and inhibition of virus infection in the host. Although there are antiviral treatments against human gammaherpesviruses, toxicity issues and the emergence of drug resistance are limitations to their use. To overcome these issues, studies are focusing on identifying alternative treatments, such as natural phytochemical products with antiviral activity against gammaherpesviruses. In this paper, we review the characteristic features of two human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV), and their related diseases. The current state of research on natural phytochemicals with anti-gammaherpesvirus activity is then discussed. Finally, we further discuss the limitations and prospects of anti-gammaherpesvirus research.