한국인에서의 빛간섭단층촬영기를 이용한 망막신경섬유층 두께 분석

Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomography in Healthy Koreans

목적: 정상안에서 빛간섭단층촬영기를 통해 평균 망막신경섬유층 두께를 측정하고, 여러 요인과의 연관성에 대해 알아보고자 하였다. 대상과 방법: 정상인 205명의 352안을 대상으로 빛간섭단층촬영기를 이용하여 망막신경섬유층 평균 두께를 측정하였다. 결과: 전체 평균 retinal nerve fiber layer 두께는 100.2 ± 10.9 μm였으며, 연령대가 높아짐에 따라 망막신경섬유층 두께가 10년당 0.8 μm씩 감소함을 보였다. 상이측, 하이측을 제외한 나머지 사분면에서 안축장 길이와 망막신경섬유층 두께 사이에 유의한 상관관계를 보였다. 결론: 이 연구는 빛간섭단층촬영기를 통하여 한국인에서의 평균 망막신경섬유층 두께를 측정하였다. 연령이 정상 망막신경섬유층 두께와 연관성이 있었으나, 연령에 따라 각기 다른 분면에서 모두 일정한 변화를 보이는 것은 아니었다.

Purpose: To determine normal retinal nerve fiber layer (RNFL) thickness by age and to investigate the relationships of the RNFL with clinical variables using spectral domain optical coherence tomography (SD-OCT) in healthy Koreans. Methods: The peripapillary RNFL thicknesses were measured around the optic disc using consecutive circular B-scans with 3.5 mm diameter and automatically calculated using a SD-OCT. Results: Three hundreds fifty-two eyes of 205 healthy subjects were included in the study and RNFL thickness were measured by SD-OCT. Overall average RNFL thickness was 100.2 ± 10.9 μm, and significantly and negatively correlated with age (r = -0.164, p = 0.002). The overall average RNFL thickness decrease per decade was 0.8 μm (95% confidence interval, -0.3 to -1.3, p = 0.019). Mean RNFL thickness of each quadrant was significantly correlated with axial length except in the superior quadrant. Conclusions: This study describes the normal RNFL thickness values of Koreans as determined by SD-OCT. Furthermore, age was found to be correlated with normal RNFL thickness, however age-related changes were not uniform across every region.