有機化合物에 對한 解毒轉機에 있어서 Cytochrome p 450의 役割의 多樣性

Many Roles of Cytochrome p450 in Detoxification of Organic compounds

Informations on the ability of cytochrome p450 on the detoxification mechanism have been provided in the basis of it’s location, determination, sepcificity and versatile roles. Cytochrome p450 are located in the endothelial reticulum of hepatic cell and can be quan-titated from microsomes separated by differential ultracentrifugation. And 4 kinds of cytoc hrome p450 fractionated by column chromatography show different protein patterns on polyacrylamide gel electrophoresis and their special inductions by various inducers. Role of cytochrome p450 in the detoxification of organic compounds such as organic medicines, organic pesticides and other organic chemicals introduced in the body can be summarized as the ability to oxidize and convert them to the water soluble compounds for their elimination.