Penicillin의 乳汁 移行에 關한 試驗

Pesistance of residual amounts of penicillin in milk of cows

Antibiotic residues in milk of cows administered penicillin either intramuscularly or intracisternally were studied by the use of 2,3,5-triphenyl tetrazolium chloride (T.T.C.) test. Residues in milk of cows by 72 hours after the administration of penicillin aqueous (10,000 I.U./kg) intramuscularly were detected in 1 of 5 cows whereas those were detected in 3 of 5 cows given oil penicillin. The time of elimination was 108 hours for the cows administered intramuscularly a dose of 20,000 I.U/kg of aqueous penicillin and 120 hours for those received 20,0000 I.U./kg of oil penicillin. When 500,000 I.U. of penicillin aqueous or oleosum was administered intracisternally, the elimination time was 72 hours for aqueous penicillin and 84 hours for oil penicillin.