항콕시디엄지수에 대한 polyether ionphorous antibiotics의 효능평가

Studies on the anticoccidial efficacy of polyether ionophorous antibiotics, salinomycin sodium, monensin sodium, and maduramicin ammonium by the anticoccidial index in chickens

The present studies were carried out to elucidate the drug resistance of field isolates of Eimeria spp. to salinomycin, one of the polyether ionophorous antibiotics, and to evaluate the efficacy of salinomycin and the related anticoccidial drugs including monensin and maduramicin, during a 14 month period from May, 1984 to July, 1985. For the trial on drug resistance, a total of 116 broiler farms in 7 major broiler-producing regions, in where salinomycin has been used for more than 5 years, has subjected. Among them, 65 farms detecting over 1.0×10⁴ coccidial oocysts were selected by regions. The fecal samples were separately collected from each farm. The oocysts of Eimeria spp. were propagated and the stock suspension for artificial inoculation were prepared by regions. A group of 220 Abor Acres strain of broiler chickens, 9 day old, was divided into 4 groups, 10 in normal control group(noninfected, non-medicated group) and 70 in each of group Ⅰ(infected, non-medicated), group Ⅱ(infected, medicated with salinomycin 50ppm) and group Ⅲ(infected, medicated with salinomycin 100ppm) respectively. The basal diet for normal control group and group Ⅰ, and medicated diet for groups Ⅱ and Ⅲ were supplied ad libitum from 48 hours before the artificial oral inoculation with about 4.0×10⁴ sporulated oocysts throughout the 8th day after inoculation.