韓國에서 츄잔病의 發生 및 binary ethylenimine 不活化 츄잔바이러스 豫防藥의 소에서의 免疫原性 試驗

An outbreak of chuzan disease in Korea and the immunogenicity of binary Ethylenimine-treated chuzan virus vaccine in cattle

Chuzan disease of which the main clinical abnormalities were impairment of mobility and nervous signs took place in a calf breeding farm in Cheju province during the period of March, 1993. The serological survey indicated that antibody to Chuzan virus was present at a high rate in Cheju province, while it was at a low rate in the Honam area of the mainland. The retrospective sero-epidemiological investigations strongly suggested that Chuzan virus comes to Korea from the Southeast Asian countries and the first outbreak of Korea is simultaneous with that of Japan. A preliminary study for development of an inactivated Chuzan virus vaccine was performed. The binary ethylenimine treated-tissue culture fluid with a gel adjuvant had good immunogenicity in cattle. To control this disease in Korea, an inactivated Chuzan virus vaccine is scheduled for practical use in the field in the near future.