抗콕시듐劑 抗生物質의 닭 體內代謝 및 殘留에 關한 硏究

Studies on pharmacokinetics and residues of polyether antibiotics in chicken

Detection for residues of polyether antibiotics(Salinomycin, Monensin, Lasalocid and Naracin) in chicken tissues-kidney, fat, liver and muscle was performed by the TLC and bioautography. B. subtillis ATCC 6633 strain, ethyl acetate and chlorform : methanol : conc. NH₄OH(95/5/0.5) solvent and addition of MgCl₂ in media were used in these experiments. Eighty chickens were divided four groups : 2 normal level feeder groups (monensin 110ppm, salinomycin 50ppm), 2 high level feeder groups(monensin 550ppm, salinomycin 250ppm) for five weeks. The recovery rate of monensin, salinomycin, lasalocid and naracin was 85.9~100.5%, 88.8%, 86.8% and 87.8% in chicken tissues at each. In high level feeder groups, monensin and salinomycin were detected about 0.052ppm and 0.085ppm at each in fat tissue at 24hours after feeding The duration of residues in high level feeder groups lasted longer than that of normal level feeder groups. Besides this test we have performed the amount of contamination of polyether antibiotics in twenty market chickens, so there is no residue of polyether antibiotics in the chiken tissue.