SLCO1B1 T521C가 스타틴에 의한 저밀도지단백 콜레스테롤 감소에 미치는 영향: 체계적 문헌고찰 및 메타분석

Effect of SLCO1B1 T521C on statin-induced reduction in low-density lipoprotein cholesterol: a systematic review and meta-analysis

Increasing number of studies have examined the effect of SLCO1B1 T521C polymorphism on lipid-lowering efficacy of statin. This study was conducted to clarify the effect of SLCO1B1 T521C on the rate of statin-induced reduction in low-density lipoprotein cholesterol (LDL-C). The databases of PubMed, Embase, Ovid, and Cochrane Library were searched for all published studies from inception to April 2018. Using the Review Manager 5, the pooled estimates of the weighted mean difference (WMD) of the percent changes of LDL-C and corresponding 95% confidence intervals (CIs) were calculated. A total of 17 cohort studies were included in this meta-analysis. The percent reduction in LDL-C was slightly higher in the statin users carrying 521TT than in the users carrying 521CC (WMD: 2.41; 95% CI: 0.15, 4.67; p=0.04). Sim-ilarly, the carriers of 521TC achieved slightly higher reduction in LDL-C than the carriers of 521CC (WMD: 2.07; 95% CI: 0.79, 3.35; p=0.002). However, no significant difference in percent reduction was found between the carriers and non-carriers of the 521C allele (TC+CC vs TT, WMD: 0.87; 95% CI: -0.67, 2.41; p=0.27). These results imply that the SLCO1B1 T521C polymorphism has little or no effect on the rate of reduction in LDL-C following statin therapy.