학술저널
쿠마린 에스테르/아미드 유도체 합성 및 아세틸콜린 분해효소 저해활성 연구
Synthesis and Acetylcholinesterase Inhibitory Activity of Coumarin Carboxylates and Carboxamides Analogs
- 대한약학회
- 약학회지
- 제62권 제4호(2018년)
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2018.08257 - 261 (5 pages)
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DOI : 10.17480/psk.2018.62.4.257
- 63
Several coumarin-3-carboxylates and 3–carboxamides were synthesized and evaluated for their AChE inhib-itory activity. The coumarin analogs were designed through a hybridization approach in which the backbone moiety of ace-tylcholine and the coumarin ring scaffold were connected together with an ester or amide linker. Most coumarin analogs exhibited weak to moderate AChE inhibitory activity. Among 6 tested compounds, 4f exhibited the best result (IC 50 = 17.32 µM).
서 론 (Introduction)
실험 방법 (Experimental methods)
결과 및 고찰 (Results and discussion)
결 론 (Conclusion)
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