갈망 : 생물학적 이해와 치료적 접근

Craving : Biological Understanding and Therapeutic Approach

Objectives ： Craving is defined as the desire for using the substance. It plays an important role in the recurrence of the substance- related disorder. The purpose of this review was to summarize the pathophysiology behind craving and pharmacological and psychological treatment of craving. Methods ： We searched and reviewed articles on craving for the substance. Results ： The neurotransmitters involved in craving are dopamine and serotonin. Dopamine acts on the enhancement of action, while serotonin acts by inhibiting the release of γ-Aminobutyric acid. Both acamprosate and naltrexone could be used for craving treatment. Moreover, cognitive behavioral therapeutic methods have been employed for the treatment. Conclusion : The systematic management of craving aimed at preventing the recurrence of substance- related disorders could result in improvement of compliance and reduction in recurrence and treatment cost.