학술저널
p-Xylene의 디니트로화와 2,3-, 2,5- 및 2,6-dinitro-p-xylene의 효율적 분리
Dinitration of p-Xylene and Practical Separation of 2,3-, 2,5-, and 2,6-Dinitro-p-xylenes
- 대한약학회
- 약학회지
- 제62권 제5호(2018년)
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2018.10362 - 365 (4 pages)
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DOI : 10.17480/psk.2018.62.5.362
- 36
A practical method for the preparation and separation of 2,3-, 2,5- and 2,6-dinitro-p-xylenes is described herein. The direct nitration of p-xylene with nitric acid (d 1.42) in the presence of sulfuric acid at 80oC afforded 2,3-, 2,5-, and 2,6- dinitro-p-xylenes in a ratio of 6.86:1:3.41, and the isomeric mixture could be readily separated by column chromatography on silica gel eluting with hexanes:EtOAc (19:1) as an eluent.
Introduction
Experimental Methods
Results and Discussion
Conclusion
References
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