
Amelioration of experimental autoimmune encephalomyelitis by Ishige okamurae
- Mee jung Ahn Jeong tae Kim Won jun Yang Yu na Choi Poornima Ekanayake Hyun ju Ko Young heun Jee Tae kyun Shin
- 대한해부학회
- Anatomy and Cell Biology
- Vol.51(4)
- 등재여부 : KCI등재후보
- 2018.12
- 292 - 298 (7 pages)
Experimental autoimmune encephalomyelitis (EAE) is a T-cell‒mediated autoimmune central nervous system disease characterized by inflammation with oxidative stress. The aim of this study was to evaluate an anti- nflammatory effect of Ishige okamurae on EAE-induced paralysis in rats. An ethanolic extract of I. okamurae significantly delayed the first onset and reduced the duration and severity of hind-limb paralysis. The neuropathological and immunohistochemical findings in the spinal cord were in agreement with these clinical results. T-cell proliferation assay revealed that the ethyl-acetate fraction of I. okamurae suppressed the proliferation of myelin basic protein reactive T cells from EAE affected rats. Flow cytometric analysis showed TCRαβ+ T cells was significantly reduced in the spleen of EAE rats with I. okamurae treatment with concurrent decrease of inflammatory mediators including tumor necrosis factor-α and cyclooxygenase-2. Collectively, it is postulated that I. okamurae ameliorates EAE paralysis with suppression of T-cell proliferation as well as decrease of pro-inflammatory mediators as far as rat EAE is concerned.
Introduction
Materials and Methods
Results
Discussion
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