디아족사이드에 의한 멜라닌 합성 촉진 효과에 미치는 TRPM 통로의 역할

Role of Transient Receptor Potential Melastatin (TRPM) Channels in the Stimulation of Melanin Synthesis by Diazoxide

The known inhibitors of Ca2+-permeable transient receptor potential melastatin (TRPM) channels, flufenamic acid (FFA) and clotrimazole significantly blocked the diazoxide-induced increase in intracellular Ca2+ concentration ([Ca2+]i) and melanin synthesis in B16 melanoma cells. H2O2 which has been shown to stimulate the activity of the TRPM channels, increased [Ca2+]i and melanin synthesis, which was significantly inhibited by FFA. These results suggest that TRPM channels may play an essential role in the diazoxide-induced melanogenesis through [Ca2+]i increase.

서 론(Introduction)

실험 방법(Experimental Methods)

결과 및 고찰(Results and Discussion)

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