Clinical Characteristics of Juvenile-onset Open Angle Glaucoma

Purpose: To demonstrate the clinical characteristics of juvenile-onset open angle glaucoma (JOAG) and to evaluate the prognostic factors for visual field (VF) progression in eyes with JOAG. Methods: The medical records of 125 eyes of 72 patients with JOAG were analyzed retrospectively. At least four reliable VF tests were required to determine the VF progression, and the progression was defined using the modified Anderson criteria. Comparisons in clinical manifestations among groups were performed using independent t-test, and generalized estimating equations were also conducted. Results: The mean follow-up duration was 94.4 ± 50.5 months. Patients with JOAG showed a male preponderance (64%), myopia (-4.99 ± 4.01 diopters) and a severe elevation of intraocular pressure (35.6 ± 10.8 mmHg). Forty-two JOAG patients (58%) had complained of symptoms associated with vision and pain; however, onethird presented with no definite symptoms. Fifty-seven patients were diagnosed with JOAG in both eyes, and they were significantly older (p = 0.039) and had a greater family history (p = 0.035) than patients with unilateral JOAG. The progression group exhibited a significantly higher intraocular pressure at the last visit (p = 0.023) than the non-progression group. Conclusions: Because patients with considerable JOAG had no definite symptoms, periodic eye examinations are needed. To prevent the VF’s progression, JOAG patients may require more careful management of intraocular pressure.