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KCI우수등재 학술저널

황산카드뮴독성의 산화적 손상에 대한 부들 추출물의 항산화 효과

Antioxidative Effect of Typha orientalis L. Extract on the Oxidative Stress Induced by Cytotoxicity of Cadmium Sulfate

DOI : 10.5668/JEHS.2019.45.1.62
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Objectives: This study was carried out to analyze the cytotoxicity of cadmium sulfate (CdSO<sub>4</sub>) and the antioxidative effect of Typha orientalis L. (TO) extract on the oxidative stress induced by cytotoxicity of CdSO<sub>4</sub> in the cultured NIH3T3 fibroblasts. Methods: For this study, the cell viability and the antioxidative effects such as the inhibitory activity of lipid peroxidation (LP) and superoxide dismutase (SOD)-like activity and xanthine oxidase (XO)-inhibitory activity were assessed. Results: The cadmium sulfate significantly decreased cell viability in dose-dependently, and XTT50 value was measured at 47.4 &#181;M of CdSO<sub>4</sub>. The cytotoxicity of CdSO<sub>4</sub> was determined as highly toxic by Borenfreund and Puerner s toxic criteria. The butylated hydroxytoluene (BHT) as antioxidant significantly increased cell viability injured by CdSO<sub>4</sub>-induced cytotoxicity in these cultures. In the protective effect of TO extract on CdSO<sub>4</sub>-induced cytotoxicity, TO extract remarkably increased the inhibitory ability of LP and XO as well as SOD-like ability. Conclusions: From the above results, it is suggested that the oxidative stress is involved in the cytotoxicity of CdSO<sub>4</sub>, and TO extract effectively protected CdSO<sub>4</sub>-induced cytotoxicity by antioxidative effects. The natural component like TO extract may be a putative therapeutic agent for treatment of the toxicity induced by heavy metallic compound like CdSO<sub>4</sub> correlated with the oxidative stress.

I. 서 론

II. 연구 방법

III. 결 과

IV. 고 찰

V. 결 론

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