Effects of Tissue Adhesive (TisseelⓇ) on Corneal Wound Healing in Lamellar Keratoplasty in Rabbits

The purpose of this study was to compare corneal wound healing between suture and sutureless lamellar keratoplasty in the rabbit eye. The tissue adhesive (TisseelⓇ, Vienna) a commercially available two component adhesive system based on human fibrinogen, which is activated by thrombin, was used. 8.0mm halfthickness lamellar keratoplasties (autotransplants) were performed on the twentyfour rabbit eyes with tissue adhesive and the other eyes were operated with 10-0 nylon continuous suture as a control, respectively. At varying periods postoperatively, they were killed and the eyes were immediately enucleated and examined by transmission electron microscopy and light microscopy. The procedure was completed by the application of a bandage soft contact lens.