To determine injection time and effective dose of ciprofloxacin in endophthalmitis and to evaluate the effectiveness of dexamethasone. In rabbits, Pseudomonas aeruginosa (2 × 10⁴ CFU/0.1 ml) was inoculated intravitreally. At 6, 12, 18, 24 hours postinoculation, single intravitreal doses of ciprofloxacin (300 μg/0.15 ml or 100 μg/0.05 ml) alone or with dexamethasone (400 μg) were given. Electrophysiological and histologic measures were utilized to rate drug effectiveness.
MATERIALS AND METHODS