The Effect of Low-and High-dose Adjunctive Mitomycin C in Trabeculectomy

To compare the effects of three different concentrations of mitomycin C (MMC) as an adjunct therapy to trabeculectomy, we reviewed 26 patients (36 eyes)who underwent trabeculectomy in which MMC was applied intraoperatively. The time of application was 5 minutes, and the concentration of MMC was 0.1 mg/ml (n = 10), 0.2 mg/ml (n = 17) and 0.4 mg/ml (n = 9), respectively. Complete success was defined by intraocular pressure (IOP) of 21 mmHg or less without medication at postoperative 3 months. There was no statistical difference among the three groups in mean age of patients, preoperative IOPs, and the numbers of premedication. The mean IOP at postoperative 3 months was significantly lower in the 0.4 mg/ml group (10.4 ± 5.5 mmHg) than in the 0.2 mg/ml group (16.1 ± 4.7 mmHg) (p < 0.05). The complete success rate in the 0.4 mg/ml group was 100%, which was significantly higher than the rate of 40% obtained with the 0.1 mg/ml group (p < 0.05), but was not significantly different to the rate of 70.6% in the 0.2 mg/ml group (p > 0.05).