Glutathione Transferase (Class π) and Tissue Transglutaminase (TGase C) Expression in Pterygia

Pterygia are considered to be induced by predisposing factors such as the external toxic environment. Glutathione transferses (GSTs) have a role in the detoxication of toxic chemicals. Transglutaminases (TGases) are involved in apoptosis, cellular adhesion and the wound healing process. As their expressions may be changed in abnormal conditions, we evaluated the clinicopathological status of pterygia by immunohistochemical study with GST-π and TGase C. Twenty one pterygia, two pseudopterygia and five normal conjunctival specimens were used. The formalin-fixed samples were embedded in paraffin blocks, which were subjected to be stained with anti-GST-π and anti-TG polyclonal antibodies immunohistochemically.