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KCI등재 학술저널

Melanosomes of Retinal Pigment Epithelium - Distribution, Shape, and Acid Phosphatase Activity

The distribution and shape of melanosomes of the retinal pigment epithelium (RPE), and acid phosphatase activity in melanosomes were studied in rabbits. The rabbit eyes were observed using electron microscopy and enzyme cytochemical electron microscopy. The majority of melanosomes were located near the apical region of the RPE. Melanosomes in the RPE were classified as two shapes, elliptical and spherical or oval. Elliptical melanosomes were located parallel to the apical process and spherical or oval melanosomes were arranged vertically or obliquely to the apical process. We think that the distribution and shape of melanosomes contributes to the effective absorption and blocking of light coming from all directions. Almost all of the mature and immature melanosomes we identified showed positive in acid phosphatase reaction, indicating that melanosomes are commonly incorporated into the lysosomal system of the RPE. However, a few melanosomes showed negative in acid phosphatase reaction, suggesting that some melanosomes are stable and inert.

Abstract

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

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