Purpose; The purpose of this study is to identify the levels of stress, self-esteem and resilience of nursing college students’ safety management and to recognize the correlations between them. Methods; The research design is a descriptive correlational study design and used convenience sampling on 203 senior nursing students in G city. The used research measures were tools which measure stress, self-esteem and resilience. Data collection was conducted from June 2, 2017 to June 15, 2017 using SPSS 21.0 for data analysis. Results; The results show that stress is affected by health status, major satisfaction and clinical practice satisfaction. Meanwhile, resilience is affected by health status, selective motivation for nursing major, interpersonal relationships, personality trait and major satisfaction. Stress and resilience are negatively correlated while self-esteem and resilience are positively correlated. In other words, an increase in stress levels correlates with a decrease in resilience and conversely, a decrease in stress levels correlates with an increase in resilience. An increase in self-esteem correlates with an increase in resilience and a decrease in self-esteem correlates with a decrease in resilience. Conclusion; Therefore, there is a need for institutions that are responsible for the education and management of nursing colleges to preferentially take interest in helping nursing students with their stress and college adjustment. In addition, if the social support system that protects nursing students is systemically formed and utilized, it can not only help increase self-esteem and resilience of nursing students but also improve their quality of life, contributing to higher level of nursing profession settings.