클로자핀 복용으로 유발된 각막 및 수정체 색소침착 1예

A Case of Clozapine-induced Corneal and Lenticular Pigmentation

Purpose: To report a case of corneal and lenticular pigmentation after prolonged clozapine therapy. Case summary: A 56-year-old male visited our hospital with a progressive decline in vision that affected both eyes. He had a history of schizophrenia. He was being treated with 200 mg clozapine and 1 mg lorazepam daily, and had been treated with clozapine for 5 years. At the first visit, his best-corrected-visual acuity was 20/32 in both eyes. Slit lamp examination of the corneas showed bright, fine, grayish-brown deposits on the endothelium, and on dilation, bilateral central stellate opacity of the anterior portion of the lens capsule was revealed. Conclusions: Clozapine may induce corneal and lenticular pigmentation and thus may lead to a decline in vision. Patients on long-term clozapine therapy should be considered for regular ophthalmic review. J Korean Ophthalmol Soc 2019;60(3):276-279