Purpose: To report a case of bilateral spontaneous anterior lens dislocation associated with retinitis pigmentosa (RP). Methods: A 45-year-old male with RP presented with elevated intraocular pressure (IOP) in the right eye and was treated with laser iridotomy (LI). After LI, complete crystalline lens dislocation into the anterior chamber occurred. Surgical intervention, including anterior vitrectomy, intracapsular cataract extraction(ICCE), and IOL scleral fixation was performed. Two years later, the same episode occurred in his left eye and a similar treatment was done. Results: Surgery was successful in both eyes. Conclusions: This is the first report of bilateral spontaneous anterior lens dislocation in a RP patient.