Phenyl m-coumarylamide 유도체의 합성 및 혈소판 응집 억제 활성
Synthesis of Phenyl m-coumarylamide Analogs and Their Anti-platelet Aggregation Activity
- 대한약학회
- 약학회지
- 제63권 제2호(2019년)
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2019.0470 - 74 (5 pages)
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DOI : 10.17480/psk.2019.63.2.70
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Phenyl m-coumarylamide analogs were designed based on phenylpropanoid analogs such as coumaric acid, ferulic acid, and caffeic amide having anti-platelet aggregation activity. They prepared through concise synthetic method. Their anti-platelet aggregation was confirmed using ADP-induced rat platelet by aggregrometer. Compound 1b and 1d having dimethylamine and methoxy group on para-position of phenylamide ring, respectively, exhibit potent inhibitory activity (92.3 and 89.3% at 80 μg/mL). The results suggest that phenyl m-coumrylamide analogs could be used to develop potent anti-platelet aggregation agents.
서 론(Introduction)
실험 방법(Experimental Methods)
결과 및 고찰(Results and Discussion)
결 론(Conclusion)
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