Phenyl m-coumarylamide 유도체의 합성 및 혈소판 응집 억제 활성

Synthesis of Phenyl m-coumarylamide Analogs and Their Anti-platelet Aggregation Activity

Phenyl m-coumarylamide analogs were designed based on phenylpropanoid analogs such as coumaric acid, ferulic acid, and caffeic amide having anti-platelet aggregation activity. They prepared through concise synthetic method. Their anti-platelet aggregation was confirmed using ADP-induced rat platelet by aggregrometer. Compound 1b and 1d having dimethylamine and methoxy group on para-position of phenylamide ring, respectively, exhibit potent inhibitory activity (92.3 and 89.3% at 80 μg/mL). The results suggest that phenyl m-coumrylamide analogs could be used to develop potent anti-platelet aggregation agents.