
N,N -(Alkanediyl)bis(phenylacetamide)유도체 합성 및 DNA methyltransferase 저해활성
Synthesis and DNA methyltransferase inhibitory activity of N,N -(alkanediyl)bis(phenylacetamide) derivatives
- 이소현(Sohyun Lee) 마은숙(Eunsook Ma)
- 대한약학회
- 약학회지
- 제63권 제2호(2019년)
- 등재여부 : KCI등재
- 2019.04
- 113 - 119 (7 pages)
DNA methyltransferases (DNMTs) are epigenetic enzymes responsible for gene expression in cancer, therefore their inhibitors have been considered as target for the treatment and prevention of cancer. Psammaplin A (PsA) with dimeric disulfide structure exhibits excellent DNMT inhibitory activity, but there are synthetic limitations in the development of various derivatives. To develop various DNMT inhibitors that are easy to synthesize, N,N -(alkanediyl) bis(phenylacetamide) derivatives 1-16 were synthesized from 3- or 4-substituted phenylacetic acids and α,ω-diaminoalkanes(NH2(CH2)nNH2, n=2-5) and evaluated for the preliminary screening of DNMT inhibitory activity using PsA as an positive control. The DNMT inhibitory activities (21-91%) of all synthesized compounds were lower than that of PsA (>100%) at 200 μM concentration. Among them, N,N -(pentane-1,5-diyl)bis(2-(3-bromophenyl)acetamide) (12) was found to be most active compound with DNMT inhibition of 91%.
서 론(Introduction)
실험방법(Experimental Methods)
결과 및 고찰(Results and Discussion)
결 론(Conclusion)