60세 이상의 한국인에게서 근육량 감소를 예측하는 인자

Low Concentrations of Serum Albumin May Predict Muscle Loss in Korean Adults Aged 60 Years and Older

Background: The factors for predicting aging-related muscle loss are not clearly identified. The aim of this study is to examine factors associated with muscle loss in Korean older adults. Methods: We assessed 329 subjects aged 60 years and older who participated in the health checkup programs twice in one to two years’ time period. Muscle loss group was defined as those with 5% or more decrease in fat-free mass. The biomarkers were compared between the muscle loss and non- loss groups adjusting for potential confounders. Results: The number of subject in muscle loss group was 30 (9.1%). Serum albumin concentration was significantly lower in the muscle loss group than that in the non-loss group. Based on the ROC curve results, serum albumin was the predictor of muscle loss (Area Under Curve=0.656). Multivariate regression results presented the odds ratio of 1 standard deviation of baseline albumin level for the muscle loss was 0.446 (95% confidence intervals 0.271-0.734, P=0.001). Conclusion: Baseline serum concentrations of albumin may be a significant indicator to predict muscle mass loss in Korean adults aged 60 years and older.