혼합치매와 알츠하이머병의 국소뇌혈류 차이

Differences in Regional Cerebral Blood Flow between Mixed Dementia and Alzheimer’s Disease

Background: Previous studies have suggested that mixed dementia (MD) has distinct characteristics of brain structure and function compared to other types of dementia such as Alzheimer disease (AD). However, the patterns of altered regional cerebral blood flow (rCBF) in MD remain elucidated. This study aimed to investigate the differences in rCBF between MD and AD patients. Methods: Twent-seven MD patients and 27 AD patients in their early stages underwent brain technetium-99m hexamethylpropy-lene amine oxime single-photon emission computed tomography scans. Voxel-wise differences in rCBF between the two groups were examined using Statistical Parametric Mapping. Results: MD patients presented lower rCBF in the superior/inferior frontal and lateral orbital gyri compared to AD patients (P＜0.005). On the other hand, AD patients demonstrated lower rCBF in the amygdala and hippocampus compared to their counterparts (P＜0.005). Conclusion: The distinct characteristics of rCBF vary by underlying dementia pathology, MD and AD.