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KCI등재 학술저널

Effect of Eleutheroside E from Eleutherococcus senticosus on the Contractility of Rabbit Penile Corpus Cavernosum Smooth Muscle

DOI : 10.17480/psk.2020.64.4.307
  • 34

The relaxant effect of extract, fractions and major component, eleutheroside E, from Eleutherococcus senticosus was evaluated on penile corpus cavernosum smooth muscle (PCCSM) in a rabbit. The PCCSM contracted with 10 μM phenylephrine (Phe) was treated with extract and three fractions partitioned with n-hexane, ethyl acetate and n-butanol at a range of 1-4 mg/ml. Eleutheroside E was tested at final concentrations of 0.1, 1, 10 and 100 μM. The interaction of eleutheroside E with phosphodiesterase type 5 (PDE5) inhibitor, udenafil, was also evaluated on PCCSM tension. The relaxations induced by ethanol extract and three fractions on PCCSM were effective in a dose-dependent manner and the relaxation of ethyl acetate fraction was the highest. Eleutheroside E dose-dependently induced the PCCSM relaxation and showed an additive effect with udenafil on PCCSM. The extract, ethyl acetate fraction and eleutheroside E from E. senticosus relaxed the Phe-precontracted PCCSM and eleutheroside E enhanced the udenafil-induced relaxation. It can be an alternative or supplement for patients with erectile dysfunction who want herbal medicines to improve penile erection or who do not completely respond to udenafil.

Introduction

Experimental Methods

Results

Discussion

Conclusion

Acknowledgment

Conflict of Interest

References

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