상세검색
최근 검색어 전체 삭제
다국어입력
즐겨찾기0
153317.jpg
학술저널

V 약침의 Sprague-Dawley Rat에 대한 단회 근육투여 독성시험

In Vivo Micronucleus Test of V-YAKCHIM in ICR Mice

  • 1

Objectives : This study was conducted to assess the toxicity and to determine approximate lethal dose of the V-YAKCHIM following a single intramuscular injection to 6-week old male and female Sprague-Dawley rats. Methods : Test groups consisted of one dosing group at a dose of 1.0 mL/animal and one control group (saline), and 5 males and 5 females were assigned to each group. All animals were monitored for clinical signs and body weight changes during the 14-day observation period after administration. They were subjected to gross necropsy at the end of the observation period. At necropsy, necropsy findings and local tolerance test at the injection site were conducted. Results : All animals in the 1.0 mL/animal group survived the duration of the study. No test substance-related effects were evident in clinical signs and necropsy findings in any animals in the 1.0 mL/animal group. In local tolerance test at the injection site, no test substance-related effects were evident in any animals in the 1.0 mL/ animal group. Conclusions : Based on the results of the single intramuscular injection in Sprague-Dawley rats, the approximate lethal dose of the V-YAKCHIM was considered to be greater than 1.0 mL/animal in male and female rats under the conditions of this study.

Ⅰ. 서 론

Ⅱ. 재료 및 방법

Ⅲ. 결 과

Ⅳ. 고 찰

Ⅴ. 결 론

참고문헌