약침 V, TA, SH의 NO 및 염증성 사이토카인 억제효과

Anti-inflammatory Activities of V, TA and SH Yakchim on LPS-induced Nitric Oxide and Pro-inflammatory Cytokines Production in Raw 264.7 Macrophages

Objectives : The purpose of this study was to investigate the anti-inflammatory activities of V Yakchim (V), TA Yakchim (TA) and SH Yakchim (SH). Methods : To investigate the anti-inflammtory effects of V, TA, and SH, nitric oxide (NO) production, interleukin-6(IL-6), and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-treated Raw 264.7 macrophages were measured. Results : V, TA and SH (100 μg/ml) decreased 17.2%, 12.7%, and 56.3% of NO production, respectively. V, TA and SH also showed anti-inflammatory effect by inhibiting IL-6, TNF-α cytokines. Conclusions : These results suggested the possibility that the anti-inflammatory effect of V, TA and SH.