60세 이상 남성에서 흡연상태에 따른 대사증후군과 중성지방/HDL 콜레스테롤 비의 관련성

Association between Metabolic Syndrome and Triglyceride to HDL-Cholesterol Ratio according to Smoking Status in Korean Men Aged 60 Years and Over

Background: Metabolic syndrome causes type 2 diabetes mellitus and increases the risk of cardiovascular disease. Insulin resistance is a common feature of metabolic syndrome. Also smoking is associated with an increased risk of insulin resistance. Recent examinations suggest that triglyceride to high density lipoprotein cholesterol (HDL-C) ratio is a major predictive index for metabolic syndrome and cardiovascular disease. The purpose of this study was to examine the association between metabolic syndrome and triglyceride to HDL-C ratio according to smoking status in Korean men aged 60 and over. Methods: Subjects for this cross-sectional study included 585 males over the age of 60 who visited the hospital for a health check-up. Anthropometric measurements and biochemical studies were conducted. Smoking status of subjects was obtained by self-reported questionnaires. Metabolic syndrome was defined according to the revised NCEP-ATP III criteria. The association between metabolic syndrome and triglyceride to HDL-C ratio according to smoking status was examined using the multiple logistic regression analysis. Results: After the adjustment for age, body mass index, alcohol and high sensitive C-reactive protein (hs-CRP), the odds ratio of highest triglyceride to HDL-C ratio group for metabolic syndrome was 36.162 (95% CI, 7.625-171.507, P＜0.001) in never smoker, 14.327 (95% CI, 6.137-33.447, P＜0.001) in ex-smoker, and 28.745 (95% CI, 7.822-105.627, P＜0.001) in current smoker, respectively, compared with those of lowest group. Conclusion: These findings show that triglyceride to HDL-C ratio is significant and a practical risk predictor of metabolic syndrome in the elderly regardless of their smoking status.