참가시나무 열수 추출물은 강한 항산화제로 xanthine oxidase반응을 억제하며 uric acid생성에 영향을 주어alfacalcidol과 ethylene glycol로 결석이 유도된 흰쥐에따르는 혈중 및 뇨의 위험요소 감소시킨 것으로 추측된다. 또한 강력한 이뇨제인 furosemide군과 비슷한 유의성을나타내었다. 따라서 참가시나무 잎 열수 추출물은 신장결석 예방과 치료를 위해 적합하다고 생각된다.
Kidney stones occur in approximately 1% of the population during their lifetime. Although the development of extracorporeal shock wave lithotripsy (SWL) has revolutionized the theraphy of urolithiasis, the rate of recurrence of urothiasis, the rate of recurrenece of stones after SWL is about 50% within 10 years, which still represents serious problems for patienes. So to clarify the mechanism of Urocalum, and QS (Quercus salicina Blume) extract in the treatment of urolithiasis. Rat calcium oxalate urolithiasis was induced by oral administration of ethylene glycol and the vitamin D3analog alfacalcidol for 14 days and QS extract was given to rats. After the last administration, we measured in urine, serum and renal oxidative stress marker. Ethylene glycol and alfacalcidol treatment increased BUN, creatinine, uric acid and XO. This increase was significantly suppressed by the administration of QS extract. These finding suggest that the QS extract plays a role in the prevention of stone formation and recureence in urolithiasis.
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