
The Analgesic Effect and Mechanisms of Dianthus chinensis L extract in the mice.
- Soo-Hyun Park Yun-Beom Sim Jin-Koo Lee Soon-Sung Lim Jin-Kyu Kim Hong-Won Suh
- 한국자원식물학회
- 한국자원식물학회지
- 제23권 제6호
- 등재여부 : KCI등재
- 2010.12
- 513 - 518 (6 pages)
In the present study, the antinociceptive profiles of Dianthus chinensis L extract were examined in ICR mice. Dianthus chinensis L extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Dianthus chinensis L extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P (0.7 g) was diminished by Dianthus chinensis L extract. Intraperitoneal (i.p.) pretreatment with yohimbine (2-adrenergic receptor antagonist) attenuated antinociceptive effect induced by Dianthus chinensis L extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by Dianthus chinensis L extract in the writhing test. Our results suggest that Dianthus chinensis L extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of Dianthus chinensis L extract may be mediated by 2-adrenergic receptor, but not opioidergic and serotonergic receptors.
Introduction
Materials and Methods
Results
Discussion
Acknowledgment
Literature Cited