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학술저널

약시, 시신경위축, 시신경염에서의 시유발전위 비교 연구

A Comparative Study of Pattern Visual Evoked Potentials between Amblyopia, Optic atrophy

Purpose: This study evaluated diagnostic use of pattern reversal visual evoked potential between amblyopia, optic atrophy, and a control group. Methods: We retrospectively examined 63 patients with amblyopia, 39 patients with optic atrophy causing decreased visual acuity and 148 patients as the control group for pattern reversal-visual evoked potential (PR-VEP) results. We compared with control group and ocular disease group based on the mean value of P100 latency, N1-P1 amplitude. The comparision with P100 latency ratio and P100 amplitude ratio was performed to confirm the difference between amblyopia and optic atrophy. Results: The mean value of P100 latency (msec) in the control group was 100.98 ± 7.76, 111.19 ± 16.00 in amblyopia, 121.88 ± 24.56 in optic atrophy and showed significant delay in both diseases (p ˂ 0.001). The mean value of amplitude (μV) in the control group was 7.40 ± 5.34 of N1-P1, 6.47 ± 3.24 in amblyopia and 4.33 ± 2.32 in optic atrophy and showed significant decrease in both diseases (p ˂ 0.001). The value of P100 latency ratio (p = 0.041) and P100 amplitude ratio (p = 0.042) between amblyopia and optic atrophy showed significant difference and there was a positive correlation for difference of visual acuity in both eyes and P100 amplitude ratio (r = 0.723, p = 0.002) and P100 latency ratio (r = 0.589, p ≤ 0.001). Conclusions: We found a significant delay of P100 latency and decreasing P100 amplitude in amblyopia and optic atrophy compared to the control group. There was a statistical difference of P100 amplitude ratio and P100 latency ratio between two diseases and this is probably because the difference of visual acuity in amblyopia is significantly smaller than optic atrophy.

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