Anti-inflammatory effect of Arctium minus on LPS-stimulated RAW 264.7 cells
Anti-inflammatory effect of Arctium minus on LPS-stimulated RAW 264.7 cells
- 한국자원식물학회
- 한국자원식물학회 학술심포지엄
- 2019년도 춘계학술대회
- 2019.04
- 115 - 115 (1 pages)
Thalictrum rochebrunianum var. grandisepalum (TRG) is a Korean endemic plant, and it is widely used for edible, medicinal, landscape materials. In this study, we examined the protein and mRNA expression levels of MITF, tyrosinase, TRP-1 and TRP-2 by TRG extract (TRGE) in IBMX-treated melanocytes to evaluate the possibility of using TRG as a whitening material. IBMX were reported as melanin synthesis enhancers. It could increase intracellular melanin synthesis by activation of the microphthalmia-associated transcription factor (MITF) signaling pathway. TRGE did not show cytotoxicity at concentrations below <TEX>$100{\mu}g/ml$</TEX> in B16F10 cells. TREG dose-dependently inhibited protein and mRNA levels of MITF, tyrosinase, TRP-1 and TRP-2. Therefore, we suggest that TRGE is an important natural resource for cosmetic raw materials for whitening function.