1-MCP(1-Methylcyclopropene) 훈증 처리가 절화 백합 '시베리아'와 '메두사'의 잎 황화와 절화 수명에 미치는 영향

Effect of 1-MCP Fumigation on the Leaf Chlorosis and Vase Life of Cut Lilies 'Siberia' and 'Medusa'

In this study, we evaluated the effect of branch (STB) and leave (STL) extracts from Sageretia thea on <TEX>${\beta}$</TEX>-catenin level in human colorecal cancer cells, SW480 and lung cancer cells, A549. STB and STL dose-dependently suppressed the growth of SW480 and A549 cells. STB and STL decreased <TEX>${\beta}$</TEX>-catenin level in both protein and mRNA level. MG132 decreased the downregulation of <TEX>${\beta}$</TEX>-catenin protein level induced by STB and STL. However, the inhibition of <TEX>$GSK3{\beta}$</TEX> by LiCl or ROS scavenging by NAC did not block the reduction of <TEX>${\beta}$</TEX>-catenin protein by STB and STL. Our results suggested that STB and STL may downregulate <TEX>${\beta}$</TEX>-catenin protein level independent on <TEX>$GSK3{\beta}$</TEX> and ROS. Based on these findings, STB and STL may be a potential candidate for the development of chemopreventive or therapeutic agents for human colorectal cancer and lung cancer.