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학술대회자료

깔라몬딘오렌지로부터 집속초음파추출을 이용한 기능성 물질 생산 공정 최적화

Process Development for Production of Functional material from Citrus Madurensis(Citrofortunella microcarpa) Using Innovative Extraction by Focused Ultrasound(INEFU).

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In this study, we investigated the effect of branch extracts from Vaccinium oldhamii (VOB) on melanin synthesis in B16F10 cells. VOB promoted melanin production in absence or presence of <TEX>${\alpha}$</TEX>-melanocyte-stimulating hormone (<TEX>${\alpha}-MSH$</TEX>) in B16F10 cells. However, VOB did not affect the expression of tyrosinase and TRP-1 associated with melanin synthesis at the mRNA and protein level in B16F10. But, VOB decreased TRP-2 protein level and induced tyrosinase activation in B16F10 cells. Inhibition of tyrosinase activity and tyrosinase knockdown attenuated VOB-mediated melanin synthesis. In conclusion, it is thought that VOB may stimulate melanin synthesis through activating tyrosinase activity.

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