Cariprazine Add-on in Inadequate Clozapine Response: A Report on Two Cases
- Domenico De Berardis Gabriella Rapini Luigi Olivieri Agostina Giardini Ida De Lauretis Nicola Serroni Laura Orsolini Michele Fornaro Felice Iasevoli Sabatino Trotta Paolo Cottura Federica Vellante Marco Alessandrini Massimo Di Giannantonio
- Clinical Psychopharmacology and Neuroscience
- Vol.19 No.1
- 등재여부 : KCI등재
- 174 - 178 (5 pages)
Cariprazine is a novel antipsychotic drug that exerts partial agonism of dopamine D₂/D₃ receptors with preferential binding to the D₃ receptor, antagonism of 5HT2B receptors, and partial agonism of 5HT1A. Currently, cariprazine has shown clinical efficacy in patients with schizophrenia and with bipolar disorder, as well as adjunctive treatment in patients with Major Depressive Disorder (MDD) and drug-resistant MDD. In the present case series, we report on two patients with treatment-resistant schizophrenia and partial response to clozapine who benefit from combination with cariprazine. The effects of cariprazine combination were remarkable also concerning the adverse metabolic effects of clozapine.