한약조제 지침서 100처방을 구성하는 생약 성분별 안전성과 상호작용에 대한 연구

A Study on Safety and Drug Interactions of Herbal Drugs that Compose 100 Herbals Medication Prescriptions

Currently in Korea, hundreds of herbs can be prescribed by an oriental medicine doctor or sold by a pharmacist to treat mild diseases or improve health conditions for the same indication. And it can be happened to the same patient at the same time. However, there is no monitoring system for the oriental medical doctors and pharmacists to check the drug interaction or duplicate the administration. Herbal medicine contains pharmacologically bioactive ingredients, and when administered without assessment of the patient s disease and/or preexisting health conditions, it may overdose, duplicate, or showed unexpected harmful effects. The study was conducted through collecting information based on the secondary research using PubChem, PubMed, etc. and the evaluation of various source of additional primary information through literature survey. The result showed if 151 herbs use without caution under supervision or monitoring, those may revealed pregnancy contraindication, severe drug indications, liver, renal, cardiovascular, and/or gastrointestinal (GI) functions and blood glucose, etc. Only 61 herbs were identified to be safe for pregnant women and the most frequency side effect is GI problems. In conclusion, the result is very meaningful but available information is still limited and need to further research in future.