당뇨 전단계 성인의 공복 혈중인슐린농도 차이에 따른 심혈관질환 위험인자, 인슐린저항성 지표, 싸이토카인과의 관련성

Association with Fasting Blood Insulin Concentration and Cardiovascular Risk Factor Disease in Prediabetic Adults. KINESIOLOGY, 2015, 17(1): 63-71. [PURPOSE] The purpose of our study was to determine whether cardiovascular risk factor disease and cytokine are associated with fasting blood insulin concentration in prediabetic adults. We also examined the protective target for metabolic disease, diabetes and cardiovascular disease in prediabetic adults with insulin resistance. [METHODS] Fifty healthy male and female university students were randomly assigned and divided into four groups[ > 5μIU/mL(n=9), 5-10μIU/mL(n=26), 10-15μIU/mL(n=7), < 15μIU/mL(n=8)]. [RESULTS] There was were significantly differences such as body fat mass(p<.05), %fat mass(p<.05), waist circumference(p<.001), HDL-C(p<.05), insulin(p<.001), PAI-1(p<.05) between groups. The effect between time and groups showed a significant difference in insulin(p<.05), HOMA-IR(p<.05). Significant positive correlation was observed between weight(r=.312), fat mass(r=.389), BMI(r=.322), waist circumference(r=.415), Glucose(r=.301), HOMA-IR(r=.998) and PAI-1(r=.045). [CONCLUSIONS] Our results showed that higher fasting insulin concentration was contributed to cardiovascular disease and diabetes. These results demonstrated that regulation of insulin resistance and inflammatory cytokines may be a beneficial therapeutic targets for preventing cardiovascular disease and diabetes.