Role of Myokine and Exercise for the Prevention of Aging. KINESIOLOGY, 2017, 19(2): 1-9. [PURPOSE] This study reviewed the current trend of the importance of exercise training-related myokine s function for the prevention of aging. [METHODS] On the basis of searching on the recent research results in pubmed and the other internet research file, we reviewed the recent research output. [RESULTS] Myokine has been regarded an important factor of exercise training and brain growth factor for the prevention of Alzheimier s disease. During exercise the release of anti-inflammatory myokine from contracting skeletal muscle controled the metabolic response, and myostatin, IL-4, IL-6, IL-10, and IL-15 con-troled skeletal muscle hypertrophy and myogenesis. BDNF and IL-6 promoted the lipid metabolism through AMPK activation. IL-1Ra, IL-10 and sTNF-R inhibited TNF-α as the pro-inflammatory cytokine. IL-15 increased the releasing volume from con-tracting muscle, and promoted the anabolic factor of muscle growth. IL-7 and IL-8 activated the angiogenesis through the more activation of C-X-C receptor signal transmission. FNDC5/Irisin pathway activated brain cell and BDNF expression through the control of neurogenesis pathway. [CONCLUSIONS] Multiple myokines released from contracting skeletal muscle, and per-formed the important key factors for skeletal muscle hypertrophy. Therefore exercise training can be suggested the important intervention program for aging prevention and aging-related dysfunction through the delayed sarcopenia. We should try to elucidate the mechanism of myokine s molecular pathway and effects.