
A Study on the Effect of Chitin, Chitosan and Dithiocarbamate Chitosan on the Nickel Toxicity in Rat liver
A Study on the Effect of Chitin, Chitosan and Dithiocarbamate Chitosan on the Nickel Toxicity in Rat liver
- 유일수(yoo il su) 최경순(Choi,Kyung-Soon) 류문희(RYU MOON HEE)
- 한국환경보건학회
- 1. 한국환경보건학회지
- 제34권 제4호
- 등재여부 : KCI우수등재
- 2008.08
- 285 - 291 (7 pages)
This study was performed to investigate the effects of Chitosan on the nickel poisoning in rats. In the study, 150 male Sprague-Dawley were used. The experimental groups were divided into four: A (30 mg/L nickel), B (30 mg/L nickel+0.2% Chitin, Chitosan and Dithiocarbamate Chitosan), C (30 mg/L nickel+0.4% Chitin, Chitosan and Dithiocarbamate Chitosan), D (30 mg/L nickel+0.8%Chitin, Chitosan and Dithiocarbamate Chitosan). The results were as flows; 1. The nickel concentration in the livers of the control group (A) was 0.153~0.186 mg/kg but the nickel concentration in the livers of the experimental decreased during the experimental period (P<0.05). 2. Metallothionenin levels in rat liver were 2.77~3.25 ug/g wet,wt in control group (A), but were 2.89~3.51 ug/g wet,wt (B), 2.97~3.62 ug/g wet,wt (C), 2.68~3.68 ug/g wet,wt (D). Resectively in the experimental groups. The experimental groups were inclined to increase compare to the control group (P<0.05). In conclusion, this study revealed a preventive effect of Chitin, Chitosan and Dithiocarbamate Chitosan against nickel toxicity. This study was performed to investigate the effects of Chitosan on the nickel poisoning in rats. In the study, 150 male Sprague-Dawley were used. The experimental groups were divided into four: A (30 mg/L nickel), B (30 mg/L nickel+0.2% Chitin, Chitosan and Dithiocarbamate Chitosan), C (30 mg/L nickel+0.4% Chitin, Chitosan and Dithiocarbamate Chitosan), D (30 mg/L nickel+0.8%Chitin, Chitosan and Dithiocarbamate Chitosan). The results were as flows; 1. The nickel concentration in the livers of the control group (A) was 0.153~0.186 mg/kg but the nickel concentration in the livers of the experimental decreased during the experimental period (P<0.05). 2. Metallothionenin levels in rat liver were 2.77~3.25 ug/g wet,wt in control group (A), but were 2.89~3.51 ug/g wet,wt (B), 2.97~3.62 ug/g wet,wt (C), 2.68~3.68 ug/g wet,wt (D). Resectively in the experimental groups. The experimental groups were inclined to increase compare to the control group (P<0.05). In conclusion, this study revealed a preventive effect of Chitin, Chitosan and Dithiocarbamate Chitosan against nickel toxicity.