디옥시리보스 1-인산에 의한 멜라닌 생성에 미치는

K+-Cl−-cotransport Mediates the Deoxyribose 1-phosphate-Induced Melanogenesis

The effect of deoxyribose 1-phosphate (dRP) on melanogenesis was investigated in B16 melanoma cells. dRP increased both reactive oxygen species (ROS) levels and melanin content in a dose-dependent manner in B16 cells. These effects were significantly reduced by apocynin (Apo) and diphenyleneiodonium (DPI), which are inhibitors of the NADPH oxidase (NOX). DIOA, a blocker of the K+-Cl−-cotransports (KCCs), significantly inhibited dRP-induced activation of KCCs and melanogenesis. The NOX inhibitors(Apo and DPI) also significantly blocked dRP-induced activation of KCCs. Collectively, these results suggest that dRP may activate KCCs through NOX-mediated ROS production, and in turn, induce melanogenesis in B16 cells.