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KCI등재 학술저널

Glutaminase 저해 항암제 개발의 최근 발전 사항들

Recent Advances in Development of Glutaminase Inhibitors as Anticancer Agents

DOI : 10.17480/psk.2021.65.5.344
  • 138

Glutaminolysis is closely related to uncontrolled tumor growth and metastasis in various glutamine-dependent cancers. As such, rewiring cancer metabolism using a glutaminolysis intervention has attracted much attention with recent progress in developing glutaminase inhibitors as anticancer agents. This review paper described the current understanding of glutaminases and their roles in cancers and small-molecule glutaminase inhibitors. In particular, recent developments of natural and synthetic glutaminase inhibitors were covered, focusing on their binding sites and isoform selectivity and briefly, on their structure-activity relationship. Some of the glutaminase inhibitors are in clinical trials, and if successful, it would lead to novel pharmacological intervention to effectively treat cancers.

서론(Introduction)

Glutaminase Isoform과암에서의 역할(Glutaminase Isoforms and Their Role in Cancer)

저분자화합물 Glutaminase 저해제(Small Molecule Glutaminase Inhibitors)

결론(Conclusion)

감사의말씀(Acknowledgment)

Conflict of Interest

References

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