기후변화 요인이 의약품 이상사례 보고에 미치는 영향에 관한 연구

A Study on the Effects of Climate Change Factors on the Adverse Drug Event (ADE) Reports Focusing on Diarrhea and Respiratory Diseases

The relationship between diarrhea and respiratory disorders and climate change has been previously elucidated. Diarrhea and respiratory diseases have been reported to the Korea Institute of Drug Safety and Risk Management (KIDS) as adverse drug events (ADEs) and as serious adverse events (SAEs) due to the occurrences of hospitalization, death, and malformations. ADEs are reported by patients, hospitals, clinics, pharmacies, manufacturers (importers), and regional drug safety centers. However, it has not been determined that the reported adverse events of diarrhea and respiratory diseases are caused by whether climate change or drugs. Here, we investigate the number of ADEs of diarrhea and respiratory diseases that were reported to the Korea Institute of Drug Safety and Risk Management (KIDS) from September 1, 2012 to October 4, 2020, and analyze them with respect to climatic factors including average temperature, daily precipitation, relative humidity, and fine dust concentration (PM10, PM2.5). Our findings suggest that none of the climate change variables are statistically associated with the reported ADEs or SAEs, and climate change has no effect on the number of reported ADEs and SAEs.