Objectives : VEGF(vascular endothelial growth factor) is a potent key mediator of angiogenesis, which is necessary during tumor growth. The goal of this study was to determine expression of VEGF in acoustic neuromas and to examine a correlation with clinical characteristics. Methods : The VEGF expression was evaluated by immunohistochemical staining with monoclonal anti-VEGF antibody in 25 cases of the acoustic neuromas. Results : All tumors showed expression of VEGF in cytoplasm of schwannoma cell. The staining density revealed an insignificant correlation between VEGF expression and tumor size, symptom duration. Conclusions : This study suggests that VEGF in acoustic tumor has a role of both angiogenesis and mitogenesis in the growth of schwannoma.
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