혀뿌리 신경집종과 동시 발생한 중이 칼시노이드 환자 1례

A case of carcinoid tumor in the middle ear cavity with neurilemmoma in the base of tongue

Carcinoid tumors are neuroendocrine tumors which arise from the enterochromaffin cells; the neoplasms grow slowly and are usually found in the gastrointestinal and bronchopulmonary systems. Carcinoid tumors in the middle ear are uncommon since the neuroendocrine cells have not been identified in middle ear mucosa. In this case, a 46-year-old man had tinnitus in right ear for a year. From otoendoscopy findings, we observed a complete perforation of right tympanic membrane and a pinkish mass like lesion at the center of the perforated tympanic membrane. Canal wall up mastoidectomy and tympanoplasty were done, and pathological findings showed cuboidal or columnar cells with small, round, and uniform nuclei; immunohistochemistry demonstrated positive for CD 56 but negative for S-100. Ki- 67 proliferation activity was low. While the patient underwent intubation for general anesthesia, a 2 cm polypoid mass was found at right base of tongue. The mass was removed by robotassisted surgery, and the pathology demonstrated neurilemmoma. The aut