Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
- 대한구강악안면외과학회
- 대한구강악안면외과학회지
- 대한구강악안면외과학회지 제48권 제1호
-
2022.023 - 12 (10 pages)
-
DOI : 10.5125/jkaoms.2022.48.1.3
- 0

Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lack of an effective OSCC biomarker and efficient molecular validation method. The aim of this study was to summarize the advances in the application of NGS in cancer research and to propose potential proteomic and genomic saliva biomarkers for NGS-based study in OSCC screening and diagnosis programs. We have reviewed four categories including definitions and use of NGS, salivary biomarkers and OSCC, current biomarkers using the NGS-based technique, and potential salivary biomarker candidates in OSCC using NGS.
I. Introduction
II. Definitions and Use of NGS
III. Salivary Biomarkers and Oral Cancer
IV. Current Cancer Biomarkers Using NGS-based Technique
V. Discussion
References
(0)
(0)