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SCOPUS 학술저널

Role of macrophages in liver cirrhosis: fibrogenesis and resolution

DOI : 10.5115/acb.21.046
  • 6

At present, chronic liver disease accounts for approximately 2 million deaths per year worldwide. Liver injury induces a series of events causing inflammation. Chronic inflammation ends in liver fibrosis. A stage of fibrinolysis occurs on stopping insult. Kupffer cells play their role to initiate inf lammatory responses, while infiltrating monocyte-derived macrophages have a role both in chronic inf lammation and fibrosis and in fibrosis resolution. Ly-6C high expressing monocytes act during fibrogenesis, while Ly-6C low expressing monocytes are restorative macrophages which promote resolution of fibrosis after end of the injury. Recent studies have identified new phenotypes, such as metabolically activated M, oxidized, which may have a role in fatty liver diseases.

Introduction

Liver Macrophages Heterogeneity

Resident Liver Macrophages (Kupffer Cells)

Kupffer Cells Initiate Hepatic Inflammation and Fibrosis

Macrophages Decelerate Fibrogenesis

Replenishment of Kupffer Cells in Liver Injury

Migrating Monocytes/Macrohages

Macrophages Classification Variants

Variants of the Classification of Macrophages

New Phenotypes of Macrophages in Fatty Liver Diseases

Conclusion

ORCID

Author Contributions

Conflicts of Interest

References

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